The Principal Scientist of Functional Genomics, based in San Diego, leads target identification and validation (TIDVAL) projects that employ cutting edge technologies in the areas of high throughput molecular biology and functional genomics (e.g., single cell/nuclei RNAseq, genome wide CRISPR screens, cis-, trans eQTLs, etc). The Principal Scientist coordinates the Early Target Discovery’s TIDVAL efforts in autoimmune, or neurological, oncology, and/or rare diseases aligned with Takeda’s related Drug Discovery Unit. This individual works collaboratively and effectively with internal and external resources in validating targets and utilizes cutting edge technologies to build persuasive cases supporting the initiation of drug discovery programs by Takeda Research.
Coordinates the Early Target Discovery’s TIDVAL efforts in autoimmune, and/or neurological and/or rare diseases with Takeda’s related Drug Discovery Unit.
Serves as project leader to identify high quality targets leading to initiation of discovery programs in alignment with Takeda Drug Discovery Unit priorities.
Designs and implement functional characterization strategies for disease associated single nucleotide polymorphisms, SNPs/genes (e.g., cis-, trans eQTLs) and rare variants identified from patient genetics
Systems-level understanding of integrated genetic, transcriptomic, and phenotypic datasets
Identifies opportunities to collaborate with partners (academic, biotech, and CRO) to enhance in-house capabilities. Leads and manages external collaborations effectively
Oversees effective and productive execution of collaborations, consortiums, and other external relationships relating to TIDVAL.
Represents own and group research findings to leadership and project teams.
Establishes project direction integrating science, key technical knowledge, and program objectives
Plays an active role in the evaluation of potential drug candidates for in-licensing
Contributes to the preparation/editing/review of documents for regulatory submission (i.e., study reports, IB’s, IND’s)
EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:
PhD degree in Genetics or functional genomics or Molecular Biology or Immunology with 8+ years experience , or
MS with 12+ years experience, or
BS with 14+ years experience
Takeda is an industry-leading, global pharmaceutical company with an unwavering dedication to putting patients at the center of everything we do. We live our values of Takeda-ism – Integrity, Fairness, Honesty, and Perseverance – and are united by our mission to strive towards Better Health and a Brighter Future for people worldwide through leading innovation in medicine.